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The bacteria have developed resistance against many of the drugs available in the market. Halgamuge "Self-Organizing Hierarchical Particle Swarm Optimizer With Time Varying Acceleration Coefficients" IEEE Trans. A well organized research comprising of analogue based drug design and molecular dynamics plays a major role in obtaining the lead molecules. Black PN, Di Russo CC, Metzger AK, Heimert TL (1992): Cloning, sequencing, and expression of the fad D gene of Escherichia coli encoding Acyl coenzyme A Synthetase. Adhinarayanan, Maheswarapu Sydulu "Particle Swarm Optimisation for Economic Dispatch with Cubic Fuel Cost Function", TENCON 2006, IEEE region conference. Acyl Co A Synthetase is an enzyme that participates in fatty acid biosynthesis. The performance of proposed cellular genetic algorithms is examined under three dynamic optimization problems with different change severities.
Gaing, "Particle Swarm Optimization to solving the economic dispatch considering generator constraints," IEEE Trans. A new hydraulic system was proposed as a solution to relieve the hydraulic resistance in the actuators. The proposed system is a four ports hydraulic cylinder fitted with a novel flow control valve. Goldenberg, "Design of a new high performance electrohydraulic actuator," in Proceedings of The International Conference on Advanced Intelligent Mechatronics, IEEE/ASME,, 1999, pp. Gao Yue-lin , Duan Yu-hong "A New Particle Swarm Optimization Algorithm with Random Inertia Weight and Evolution Strategy" International Conference on Computational Intelligence and Security Workshops 2007. Guimin Chen, Xinbo Huang, Jianyuan Jia and Zhengfeng Min " Natural Exponential Inertia Weight Strategy in Particle Swarm Optimization" 6th World Confress on Intelligent Control and Automation, June 21 - 23, 2006, Dalian, China. Jong-Bae Park, Yun-Won Jeong, Hyun Houng Kim and Joong-Rin Shin "An Improved Particle Swarm Optimization for Economic Dispatch with Valve-Point Effect" International Journal of Innovations in Energy Systems and Power, Vol. Therefore by emphasizing this protein as a drug target can help in the identification of novel drugs to cure leprosy. Black PN, Zhang Q, Weimar JD, Di Russo CC (1997): Mutational analysis of a fatty Acyl-coenzyme A Synthetase signature motif identifies seven amino acid residues that modulate fatty acid substrate specificity. Key words: cellular genetic algorithm, dynamic optimization, density dependence scheme Reference  R. The activation of fatty acids by Acyl-Co A Synthetase is the need of de novo lipid biosynthesis, fatty acid catabolism and remodeling of biological membranes. The computation results indicate that new algorithms demonstrate their superiority respectively on both convergence and diversity.